Dementia & Alzheimer’s Disease
Jake Ames, MD, HMD
Puerto Vallarta, Mexico
March 8,2024
Breaking Alzheimer’s: A 15 year crusade to expose the cause and deliver the cure by Dayan Goodenowe
The End of Alzheimer’s by Dale Bredesen
Brain Maker by David Perlmuter
The Plant Paradox by Steve Gundry
Dementia is a global cognitive decline in brain function. It is a decline in mental abilities: writing, reading, speaking, reasoning, following a conversation, calculating, organizing and planning. Alzheimer’s is the most common dementia.
Types of Dementia:
Vascular dementia caused by reduced blood supply to the brain: small strokes, arteriosclerosis, diabetes, hypertension, homocysteine. There may be sensory and motor findings.
Frontotemporal Dementia:
Is much less common than Alzheimer’s disease and the cause is unknown. Results in memory problems, behavior changes, difficulty in speaking. Judgment and problem solving is more prominent than memory loss.
Lewy Body Dementia:
There is the presence of a protein called alpha-synuclein (Lewy Bodies) resulting in visual hallucinations, increased sleeping, delusions, flailing of limbs, disturbed REM sleep. Parkinson’s symptoms and dementia begin together simultaneously. No etiology.
Lewy Body
Dementia Stages: Subjective Cognitive Impairment (SCI)
Memory loss, but neuropsychological tests are normal. MRI may show brain shrinkage, and PET scans may be abnormal.
Later Stage: Mild Cognitive Impairment (MCI)
The person can perform daily activities such as eating, dressing, and bathing. Memory, speaking, calculating, plannning, and other abilities are abnormal.
Dr. Aloysius Alzheimer (1864-1915)
In 1906 Dr. Alzheimer reported amyloid plaques and long stringy tangles of proteins called tau in autopsied brains of dementia patients.
Alzheimer’s Disease:
This is the most common form of dementia. Alzheimer’s and other dementia’s exert a frightening toll on family and friends. Alzheimer’s patients usually require a very expensive total care for a few years before they die. With aging populations, dementia will bankrupt very many (already bankrupt?) countries. It is vital to do everything possible to delay , prevent or reverse the onset of dementia.
Histological Diagnosis:
Neurofibrillary Tangles (NFT’s); Beta Amyloid Plaques; Abnormal ‘Dystrophic’ Neurites (neuronal processes) associated with the beta amyloid plaques.
Amyloid Plaque
Alcohol Brain
Cocaine Brain
Three Alzheimer’s Subtypes:
Non-Inflammatory: Cortical
Inflammatory:
Increased CRP-HS; Increased Fibrinogen; Decreased A/G ratio
Non-Inflammatory:
CRP-HS and Fibrinogen are not increased. Metabolic abnormalities such as hyperinsulinemia, low vitamin D, elevated homocycteine, presenting in a person’s 80 rather in the 70’s like the first type.
Cortical:
Affecting younger individuals, usually 50’s to early 70’s. More widely distributed across the brain than the other subtypes (chermicals, heavy metals, hypothyroidism, low hormones).
Apolipoprotein E (Apo E):
Apolipoprotein E (Apo E) is a lipoprotein that carries lipids and is inherited from parents. It is the strongest genetic risk factor for developing Alzheimer’s disease.
Apo E4 Genetic Risk:
Lifetime risk of developing dementia: Zero alleles (from parents about 9% risk; one allele 30% risk; two alleles 50-90% risk
Alzheimer’s Disease is a Protective Response:
to toxins, inflammation, and inadequate general and synapse-supporting nutrition.
Dementia Causes:
Toxins:
Including heavy metals (mercury, lead, aluminum, cadmium); biotoxins (mold toxins, Lyme endo and exotoxins); various chemicals, alcohol
Nutritional Inadequacy:
Incorrect protein : fat : carbohydrate ratios. Aim for a 1 : 2.5-3.5 : 0.3-0.5 ratio. Read ‘Homo Optimus’ by Jan Kwasniewski, M.D. and ‘The Plant Paradox’ by Steven Gundry.
Inadequate nutrients: minerals e.g. lithium, magnesium, selenium, vitamins-mainly B12, B1, B6, A, D3, and the MTHFR mutations
Hormone Deficiencies:
Low levels of Estradiol (E2), DHEA-Sulfate, Progesterone, Pregnenolone, Thyroid Hormones (free T3 and free T4)
Infections:
Herpes 1 & 2, EBV, CMV, HHV-6, Mycoplasma, Chlamydia, Ehrlichiosis, Babesia, Anaplsma, Leptospirosis, Tularemia, Rocky Mountain Spotted Fever
Inflammation-Cardiovascular:
Cholesterol/HDL ratio >3.5 (<2.5 ideal), hyperlipoprotein (a). Elevated triglycerides, excess soft plaque (Lp-PLA2), homocysteine (>6 mmol/L). Keep homocysteine between 4-6 mmol/L), hypertension
Inflammation – Mouth:
Periodontal disease, gingivitis, chronic tonsillitis, abcessed teeth, failing endodontics, necrotizing inflammatory osteomylelitis, mercury amalgam dental fillings, nickel crowns, root canals
Inflammation – Autoimmune:
Over 80 autoimmune diseases. Screen with Antinuclear Antibody Test (ANA). Examples: Lupus, Rheumatoid Arthritis, Diabetes Type 1, Hashimoto’s, Graves Disease.
Inflammation – Wear & Tear:
Degenerative arthritis (DJD), senescent (zombie) cells and tissues, arteriosclerotic arteries
Cancer:
Cancer and standard treatments: Chemotherapy (chemo brain), radiation therapy, and surgery. Anesthetics cause brain damage (fluoride), decreased oxygen (sleep apnea)
Dietary Causes:
Drinking soft drinks and diet colas (aspartame). Eating gluten, GMO foods, high fructose corn syrup, excess alcohol
Other Causes:
Statin drugs, proton pump inhibitors (lower stomach HCL, hence poorer mineral absorption). Eating sugar and hydrogenated fats, lack of sleep and exercise, smoking, stress causing elevated cortisol levels, lack of sunshine (vitamin D), lack of social activities and interpersonal relationships, lack of intermittent fasting, eating at bedtime causing contantly elevated insulin levels, eating too many large fish (mercury), not brushing and flossing teeth (P. gingivalis) in the brain.
Photo I took in Paris, France. I’ve probably read every book written in English on pyramids.
Diagnosing Alzheimer’s
Blood Labs: CBC, Complete Chemistry Panel including the lipid panel, GGT, A/G ratio, ionized calcium urinalysis, Apolipoprotein E (Apo E), MTHFR Mutation, Homocysteine, Lipoprotein (a), CRP-HS, Fibrinogen, 25-OH vitamin D, vitamin A, Vitamins B1, B6 B12, Folate, RBC copper, RBC zinc, RBC manganese, RBC magnesium RBC selenium, RBC cobalt, RBC chromium, ANA, DHEA-sulfate, FSH (women), estradiol, estrone, testosterone, pregnenolone, progesterone, total T4, Total T3, Free T3, TSH, anti-microsomal thyroid antibody, anti-thyroglobulin antibody, fasting insulin, Hemoglobin A1C, Hair Elements Test (Doctors Data, Inc. (https://www.doctorsdata.com),
Parasite testing: Neurocysticercosis (Taenia solium, a pork tapeworm), Toxoplasmosis, cerebral malaria, Schistosomiasis, Echinococcus.
RPR test for syphilis, Lyme IgM Western Blot from IgeneX labs and coinfections (Babesia, Bartenella, Ehrlichia, Rocky Mountain Spotted Fever, Anaplasma, Tularemia, Rickettsia, Leptospirosis (https://igenex.com)
The problem you will have when your family member has dementia, over 95% of world doctors cannot interpret these tests! Reference ranges on laboratory tests are usually not optimal ranges. You need to find a doctor who has been practicing medicine for over 20 years and specializes in seeing the most difficult chronic degenerative disease patients.
Quantitative Neuropsychological Testing:
Montreal Cognitive Assessment (MoCA); Mini-Mental State Examination (MMSE); Self-Administered Gerocognitive Exam
Radiological Tests:
MRI with Volumetrics (Neuroreader (https://brainreader.net) or NeuroQuant (https://www.cortechslabs.com/neuroquant); Amyloid PET (positron-emission tomography)
Neuronal Exosomes:
These are tiny fragments of cells, materials, exosomes, secretions, and detritus from nerve cells. It is experimental now, but I will talk about it later on the treatment for Alzheimer’s disease.
Interpreting Lab Tests:
Here are some optimal ranges: Lipoprotein (a) <20 mg/dl; Homocysteine 4-6 umol/L; Fibrinogen 150-300 mg/dl; CRP-HS <1 mg/L; Cholesterol/HDL <3.5 (<2.5 ideal); Cholesterol 170-250 mg/dL; LDL Cholesterol 100-130 mg/dL; Hormones: Females Estradiol (E2) : Estrone (E1) 2:1; Males Estradiol 20-30 pg/ml; DHEA-Sulfate (men & women) 250-300 ug/mL; FSH (women) <20 mlU/mL, Progesterone (post-menopause) 3 ng/mL; Progesterone (male) 0.7-1 ng/mL; Pregnenolone 200-250 ng/dL (A low normal pregnenolone with an optimal DHEA-Sulfate level is fine. The Pregnenolone is being converted into DHEA.)
Treating Dementia
Treating dementia is very complex because of the many etiologies. I use EDTA, Methylene Blue, chelation, DMPS chelation, IV glutathione, Plasmalogens, IV Phosphatidlycholine, safe removal of all root canals and mercury amalgam dental fillings, Myers cocktaiil, IV ozone therapy, Plasmapheresis, FAR IR sauna, MCT oils, coconut oil, beef tallow, organic early harvest olive oil, education of the caregivers on avoiding all seed oils. I detox the COVID spike protein. I correct inflammation and hormone deficiencies. Patients are usually on a ketogenic diet while undergoing treatments. Is important to cure Lyme disease and all infections.
Jake Ames, MD, HMD
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